Neel
Joshi
Associate Professor
Chemistry
Synthetic Biology, Materials Chemistry, Chemical Biology. We envision a future in which engineered biological systems are integral to human prosperity. Engineering biology has the potential to improve many areas of modern society through new sustainable manufacturing practices, biomedical innovations that communicate with our bodies reciprocally, and responsible stewardship of our ecology. Toward these ideals, our group seeks to develop new ways that genetically engineered microbes can build and interface with their environments in ways that are prescribed by biotechnologists. A central area of investigation has been on the development of bacterial systems that produce protein nanofibers (i.e., "curli" fibers) as a scaffold for materials fabrication. We call this platform technology Biofilm Integrated Nanofiber Display (BIND), and have pursued its application in bioremediation, sustainable plastics alternatives, and gut-targeted therapeutics. We are also exploring the use of engineered bacteria to drive pH, color, and shape changes for materials, and the development of engineered living systems for highly parallelized biosensing.